Independent Health Writing

Health Clarity in a Noisy World

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STEP-1 Trial: Body Weight Change Over 68 Weeks Line chart showing semaglutide 2.4mg resulted in −14.9% average body weight change versus −2.4% for placebo over 68 weeks. Source: Wilding et al. NEJM 2021. STEP-1 TRIAL · BODY WEIGHT CHANGE Semaglutide 2.4mg vs. placebo · 68 weeks · n = 1,961 Body weight change (%) 0 −5 −10 −15 % 0 20 40 68 Week 68 wks −14.9% Semaglutide −2.4% Placebo −9.8% at wk 20 most rapid loss phase Semaglutide 2.4mg weekly (n = 1,306) Placebo (n = 655) Wilding et al. N Engl J Med 2021; 384:989–1002 · doi:10.1056/NEJMoa2032183
Average body weight change from STEP-1 trial. Semaglutide 2.4mg vs. placebo over 68 weeks. Source: Wilding et al., NEJM 2021.